At SkillCell, we’re revolutionizing olfactory science with SMILE, an innovative patented method (WO2025141188) that captures real-time emotional responses induced by fragrances through a non-invasive saliva-based technology. This approach leverages unique biological markers to measure emotions with precision, without disrupting the individual’s natural state.

Fragrances have long been associated with powerful emotional responses. However, accurately measuring these emotions in real-time has posed a significant scientific challenge. Our collaboration with CNRS and MANE, along with our proprietary saliva analysis technology, enables us to decode these emotions by identifying unique biological responses. SMILE is included in MANE’s WELLMOTION™ program. It offers a new emotional signature, helping perfume creators to design scents that target specific emotional experiences.

Our results have already been shared with the scientific community through a preprint publication on bioRxiv (read here), further validating the robustness of our approach.

The consortium of SkillCell, CNRS, and MANE is a powerful blend of expertises, bringing together biotech innovation, scientific rigor, and art of perfumery.

• SkillCell leads with its cutting-edge, non-invasive technology to capture real-time emotional responses through saliva-based analysis.
• CNRS adds unparalleled scientific expertise, ensuring the process is both innovative and rigorously validated.
• MANE, a leader in fragrance creation, translates these insights into emotionally resonant scents.

Together, we create a unique synergy that revolutionizes how we measure and design fragrances, blending science and art to craft scents that evoke specific emotions.

Our approach is simple yet powerful:

1. A participant is exposed to a fragrance.
2. A quick, non-invasive saliva sample is collected.
3. Using advanced biological markers, we capture and analyze the emotional reaction in real time.

This technology not only provides unprecedented insights into the emotional effects of fragrances but also opens new doors for tailored fragrance formulation. By understanding how specific scents evoke particular emotions, companies can create bespoke products designed to resonate with their target audience’s emotional needs.

SkillCell is paving the way for data-driven decisions in the fragrance industry, helping brands better connect with consumers on an emotional level. The future of perfume creation is here, and it’s supported by science.

While SMILE was first applied to the world of fragrances, its potential goes far beyond. The ability to capture emotional responses through non-invasive biological markers opens new avenues for neuromarketing, consumer research, and product design across industries. From food and beverages to digital experiences and retail environments, our patented technology offers brands the opportunity to objectively measure emotions in real time, creating a new standard for understanding consumer perception and decision-making.

Interested in discovering how our technology can help your company? Contact us today!